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德国NeuroConn多功能经颅电刺激器 DC-Stimulator PLUS

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简介 用于非侵入性经颅电刺激研究成熟的刺激装置,支持tDCS,tACS,tRNS,4x1HD-tDCS
品牌 德国 NEUROCONN
型号 DC-Stimulator PLUS
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脑盒(北京)科技有限公司为德国NeuroConn系列经颅电刺激产品中国区代理,NeuroConn是德国NeuroCare集团旗下技术品牌。


    德国NeuroConn DC-STIMULATOR PLUS是一款非常成熟完善的科研级tES设备,在已发表的经颅电刺激相关文献中大量应用。支持经颅直流电刺激tDCS,经颅交流电刺激tACS,经颅随机噪声刺激tRNS,通过配置4x1模块可以支持4x1高精度经颅电刺激HD-tES。除了标准功能,如微处理器控制的恒流电源外,它还包括一系列先进的可选功能,如双盲伪刺激控制,模拟信号控制,实时信号输出,和MRI兼容,可供选择的范围使设备高度可配置和适合各种应用范式。


    通过硬件和软件双重方式对电流进行多级监控,刺激器达到了极高的安全标准。通过连续监测电极阻抗,刺激器能够准确维持用户定义的电流强度,同时自动检测是否与皮肤接触不足,自动终止刺激,确保受试者安全。


研究模式用于双盲对照试验

德国NeuroConn DC-STIMULATOR PLUS可选配支持双盲对照试验的研究模式选配。该选项允许用户选择一个预定义的刺激参数协议,根据操作者输入的5位代码,输出电流刺激电流或者伪刺激电流。在这两种情况下,刺激器显示将显示相同的信息,保证操作人员和被试严格处于双盲状态。


核磁兼容功能

德国NeuroConn DC-STIMULATOR PLUS提供MRI兼容升级选配,可随机订购或者后续单独升级。刺激器经过特别优化保证在核磁环境下接入射频阻抗的情况下刺激电流能够达到2mA。得益于在fMRI环境下提供无干扰刺激的高可靠性,"DC-STIMULATOR MR" 已经成为多数tES-MR研究中共同选用的核磁兼容经颅电刺激装置,可以满足1.5T和3.0T核磁环境下使用需要。如需在7.0T核磁环境下使用,需提前申明。


EEG系统高兼容性

德国NeuroConn DC-STIMULATOR PLUS通过3种不同“Signal Output”信号输出选配,DC-Stimulator PLUS非常适合与不同类型的脑电系统进行整合兼容使用。通过这一选配功能,刺激器可以将刺激波形信息(如幅值、频率、波形等)以模拟信号的形式在线同步提供给脑电系统或者其他记录装置。所记录到的刺激信号可以用于脑电数据的online或者offline处理。该选项在需要外部设备监控刺激器输出的试验应用中也很有用,比如需要同步进行视觉或者其他刺激。


外部刺激控制功能

德国NeuroConn DC-STIMULATOR PLUS通过额外的模拟信号输入功能模块”Remote Option”可以实现远程刺激参数在线调整。这对于需要时间锁定、同步和/或变化刺激参数的研究应用尤其有用;例如tES-EEG应用和双位点tACS应用。


个性化精准定位软件实现精准刺激

支持选配tES LAB个体化定位导航软件,通过基于本地导入被试个体影像数据,进行个体化精准仿真模拟和刺激方案优化,满足被试个体化精准刺激需要。


neuroConn DC-STIMULATOR PLUS

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Floel, A and Cohen, LG. (2007). Contribution of noninvasive cortical stimulation to the study of memory functions. Brain research reviews, 53(2), 250--259.
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Fregni, F and Boggio, PS and Nitsche, M and Pascual-Leone, A. (2005). Transcranial direct current stimulation. The British Journal of Psychiatry, 186(5), 446--447.
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Fregni, F and Marcondes, R and Boggio, PS and Marcolin, MA and Rigonatti, SP and Sanchez, TG et  al and Nitsche, MA and Pascual-Leone, A. (2006). Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. European Journal of Neurology, 13(9), 996--1001.
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Fregni, Felipe and Boggio, Paulo S and Lima, Moises C and Ferreira, Merari JL and Wagner, Tim and Rigonatti, Sergio P and Castro, Anita W and Souza, Daniel R and Riberto, Marcelo and Freedman, Steven D and others. (2006). A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury. Pain, 122(1), 197--209.
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Fregni, Felipe and Boggio, Paulo S and Mansur, Carlos G and Wagner, Tim and Ferreira, Merari JL and Lima, Moises C and Rigonatti, Sergio P and Marcolin, Marco A and Freedman, Steven D and Nitsche, Michael A and others. (2005). Transcranial direct current stimulation of the unaffected hemisphere in stroke patients. Neuroreport, 16(14), 1551--1555.
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Fregni, Felipe and Boggio, Paulo S and Nitsche, Michael A and Marcolin, Marco A and Rigonatti, Sergio P and Pascual-Leone, Alvaro. (2006). Treatment of major depression with transcranial direct current stimulation. Bipolar disorders, 8(2), 203--204.
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Fregni, Felipe and Boggio, Paulo S and Nitsche, Michael A and Rigonatti, Sergio P and Pascual-Leone, Alvaro. (2006). Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression. Depression and anxiety, 23(8), 482--484.
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Fregni, Felipe and Boggio, Paulo S and Nitsche, Michael and Bermpohl, Felix and Antal, Andrea and Feredoes, Eva and Marcolin, Marco A and Rigonatti, Sergio P and Silva, Maria TA and Paulus, Walter and others. (2005). Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Experimental brain research, 166(1), 23--30.
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Fregni, Felipe and Boggio, Paulo S and Santos, Marcelo C and Lima, Moises and Vieira, Adriana L and Rigonatti, Sergio P and Silva, M Teresa A and Barbosa, Egberto R and Nitsche, Michael A and Pascual-Leone, Alvaro. (2006). Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease. Movement disorders, 21(10), 1693--1702.
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Fregni, Felipe and Freedman, Steven and Pascual-Leone, Alvaro. (2007). Recent advances in the treatment of chronic pain with non-invasive brain stimulation techniques. The Lancet Neurology, 6(2), 188--191.
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Fregni, Felipe and Pascual-Leone, Alvaro. (2007). Technology insight: noninvasive brain stimulation in neurology--perspectives on the therapeutic potential of rTMS and tDCS. Nature Reviews. Neurology, 3(7), 383.
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Iyer, MB and Mattu, U and Grafman, J and Lomarev, M and Sato, S and Wassermann, EM. (2005). Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology, 64(5), 872--875.
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Kincses, Tamas Z and Antal, Andrea and Nitsche, Michael A and Bártfai, Orsolya and Paulus, Walter. (2004). Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human. Neuropsychologia, 42(1), 113--117.
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Lang, Nicolas and Siebner, Hartwig R and Ernst, Diana and Nitsche, Michael A and Paulus, Walter and Lemon, Roger N and Rothwell, John C. (2004). Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects. Biological psychiatry, 56(9), 634--639.
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Lang, Nicolas and Siebner, Hartwig R and Ward, Nick S and Lee, Lucy and Nitsche, Michael A and Paulus, Walter and Rothwell, John C and Lemon, Roger N and Frackowiak, Richard S. (2005). How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?. European Journal of Neuroscience, 22(2), 495--504.
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Liebetanz, D and Nitsche, MA and Paulus, W. (2003). Pharmacology of transcranial direct current stimulation: missing effect of riluzole. Supplements to Clinical neurophysiology, 56, 282--287.
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Liebetanz, David and Fregni, Felipe and Monte-Silva, Katia K and Oliveira, Manuella B and Amancio-dos-Santos, Angela and Nitsche, Michael A and Guedes, Rubem CA. (2006). After-effects of transcranial direct current stimulation (tDCS) on cortical spreading depression. Neuroscience letters, 398(1), 85--90.
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Liebetanz, David and Klinker, Florian and Hering, Diana and Koch, Reinhard and Nitsche, Michael A and Potschka, Heidrun and L. (2006). Anticonvulsant effects of transcranial direct-current stimulation (tDCS) in the rat cortical ramp model of focal epilepsy. Epilepsia, 47(7), 1216--1224.
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Marshall, Lisa and Molle, Matthias and Hallschmid, Manfred and Born, Jan. (2004). Transcranial direct current stimulation during sleep improves declarative memory. Journal of Neuroscience, 24(44), 9985--9992.
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Marshall, Lisa and Molle, Matthias and Siebner, Hartwig R and Born, Jan. (2005). Bifrontal transcranial direct current stimulation slows reaction time in a working memory task. BMC neuroscience, 6(1), 23.
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Matsunaga, Kaoru and Nitsche, Michael A and Tsuji, Sadatoshi and Rothwell, John C. (2004). Effect of transcranial DC sensorimotor cortex stimulation on somatosensory evoked potentials in humans. Clinical Neurophysiology, 115(2), 456--460.
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Miranda, Pedro Cavaleiro and Lomarev, Mikhail and Hallett, Mark. (2006). Modeling the current distribution during transcranial direct current stimulation. Clinical neurophysiology, 117(7), 1623--1629.
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Nitsche, MA and Fricke, K and Henschke, U and Schlitterlau, A and Liebetanz, D and Lang, N and Henning, S and Tergau, F and Paulus, W. (2003). Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. The Journal of physiology, 553(1), 293--301.
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Nitsche, Michael A and Jaussi, Wiebke and Liebetanz, David and Lang, Nicolas and Tergau, Frithjof and Paulus, Walter. (2004). Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology, 29(8), 1573.
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Nitsche, Michael A and Lampe, Christian and Antal, Andrea and Liebetanz, David and Lang, Nicolas and Tergau, Frithjof and Paulus, Walter. (2006). Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex. European Journal of Neuroscience, 23(6), 1651--1657.
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Nitsche, Michael A and Liebetanz, David and Lang, Nicolas and Antal, Andrea and Tergau, Frithjof and Paulus, Walter. (2003). Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clinical Neurophysiology, 114(11), 2220--2222.
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Nitsche, Michael A and Nitsche, Maren S and Klein, Cornelia C and Tergau, Frithjof and Rothwell, John C and Paulus, Walter. (2003). Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. Clinical Neurophysiology, 114(4), 600--604.
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Nitsche, Michael A and Paulus, Walter. (2001). Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology, 57(10), 1899--1901.
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Paulus, Walter. (2004). Outlasting excitability shifts induced by direct current stimulation of the human brain. Supplements to Clinical neurophysiology, 57, 708--714.
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Poreisz, Csaba and Boros, Klara and Antal, Andrea and Paulus, Walter. (2007). Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients. Brain research bulletin, 72(4), 208--214.
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Power, Hollie A and Norton, Jonathan A and Porter, Cheryl L and Doyle, Zoe and Hui, Isaiah and Chan, K Ming. (2006). Transcranial direct current stimulation of the primary motor cortex affects cortical drive to human musculature as assessed by intermuscular coherence. The Journal of physiology, 577(3), 795--803.
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Quartarone, Angelo and Morgante, Francesca and Bagnato, Sergio and Rizzo, Vincenzo and Sant'Angelo, Antonino and Aiello, Elena and Reggio, Ester and Battaglia, Fortunato and Messina, Corrado and Girlanda, Paolo. (2004). Long lasting effects of transcranial direct current stimulation on motor imagery. Neuroreport, 15(8), 1287--1291.
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Rogalewski, Andreas and Breitenstein, Caterina and Nitsche, Michael A and Paulus, Walter and Knecht, Stefan. (2004). Transcranial direct current stimulation disrupts tactile perception. European Journal of Neuroscience, 20(1), 313--316.
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Siebner, Hartwig R and Lang, Nicolas and Rizzo, Vincenzo and Nitsche, Michael A and Paulus, Walter and Lemon, Roger N and Rothwell, John C. (2004). Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex. Journal of Neuroscience, 24(13), 3379--3385.
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Uy, J and Ridding, MC. (2003). Increased cortical excitability induced by transcranial DC and peripheral nerve stimulation. Journal of neuroscience methods, 127(2), 193--197.
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Vines, Bradley W and Schnider, Nora M and Schlaug, Gottfried. (2006). Testing for causality with transcranial direct current stimulation: pitch memory and the left supramarginal gyrus. Neuroreport, 17(10), 1047.
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Wagner, Timothy and Valero-Cabre, Antoni and Pascual-Leone, Alvaro. (2007). Noninvasive human brain stimulation. Annu. Rev. Biomed. Eng., 9, 527--565.
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Wassermann, Eric M and Grafman, Jordan. (2005). Recharging cognition with DC brain polarization. Trends in cognitive sciences, 9(11), 503--505.
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Wu, Allan D and Fregni, Felipe and Simon, David K and Deblieck, Choi and Pascual-Leone, Alvaro. (2008). Noninvasive brain stimulation for Parkinson’s disease and dystonia. Neurotherapeutics, 5(2), 345--361.
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Yamamoto, Yoshiharu and Struzik, Zbigniew R and Soma, Rika and Ohashi, Kyoko and Kwak, Shin. (2005). Noisy vestibular stimulation improves autonomic and motor responsiveness in central neurodegenerative disorders. Annals of neurology, 58(2), 175--181.
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